Proteasome-dependent down-regulation of activated Stat5A in the nucleus
نویسندگان
چکیده
منابع مشابه
Proteasome-dependent down-regulation of activated Stat5A in the nucleus.
A broad spectrum of cytokines can activate the signal transducer and activator of transcription 5 (Stat5) by inducing a single tyrosine phosphorylation of the molecule. Although the process of Stat5 activation has been well studied, the mechanism by which it is inactivated is not fully understood. We demonstrate that the proteasome inhibitor MG132, but not the nuclear export inhibitor leptomyci...
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ژورنال
عنوان ژورنال: Blood
سال: 2006
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2005-12-4777